Using reverse vaccinology to identify novel antigens for vaccine development against Mannheimia haemolytica as a model for bacterial agents associated with bovine respiratory disease.

Mannheimia haemolytica is a bacterial pathogen associated with bovine respiratory disease (BRD) in cattle. This condition poses significant health & economic issues for the North American cattle industry due to production losses, treatment costs and mortalities.

By sequencing and comparing the genomes of virulent and commensal strains of M. haemolytica, our goal is to identify conserved antigens in virulent strains. Once established, target antigens will be used to develop a vaccine offering cattle protection against M. haemolytica-associated BRD.